Nano anti-cancer drug carriers loaded with antineoplastic drugs can achieve targeted drug\ndelivery, which enriches drugs at tumor sites and reduces the toxic side effects in normal tissues.\nMesoporous silica nanoparticles (MSN) are good nano drug carriers, as they have large specific\nsurface areas, adjustable pore sizes, easily modifiable surfaces, and good biocompatibility. In this\nwork, polyethyleneimine (PEI) grafted MSN were modified with folic acid (FA) as an active target\nmolecule using chemical methods. The product was characterized by SEM, TEM, Zetasizer nano,\nFTIR, and an N2 adsorption and desorption test. MSN-PEI-FA are porous nano particles with an\naverage particle size of approximately 100 nm. In addition, the loading rate and release behavior\nof MSN-PEI-FA were studied with curcumin as a model drug. The results show that when loading\ncurcumin to MSN-PEI-FA at 7 mg and 0.1 g, respectively, the encapsulation efficiency was 90% and\nthe cumulative release rate reached more than 50% within 120 h at pH = 5. This drug delivery system\nis suitable for loading fat-soluble antineoplastic drugs for sustained release and pH sensitive delivery.
Loading....